Contact Information

Email: cth6@columbia.edu
Tel: 212.854.6542

Education

B.S., Biomedical Engineering, 1990, Brown University
M.S.E., Biomedical Engineering, 1992, University of Pennsylvania
Ph.D., Bioengineering, 1995, University of Pennsylvania

Curriculum Vitae

Awards (Selected)

  • 1996: Instructor Solomon Pollack Award for Graduate Research
  • 1997: Whitaker Special Opportunity Award Postdoctoral Fellowship (Center for Biomedical Engineering, Columbia University)
  • 2000: Guest editor, Cell & Tissue Engineering issue of Journal of Biomechanical Engineering (June issue)
  • 2002: Kim Award for Faculty Involvement
  • 2003: Negma-Lerards Prize, 3rd International Symposium on Mechanobiology of Cartilage and Chondrocyte, Brussels, Belgium, May 16-17
  • 2004: Co-author, The John Paul Stapp Best Paper Award in the 2003 Stapp Car Crash Journal presented at the 47th Stapp Car Crash Conference. A tissue level tolerance criterion for living brain developed with an in vitro model of traumatic mechanical loading(Morrison III, B lead author)
  • 2006-present: Associate editor, Journal of Biomechanical Engineering
  • 2008-present: Deputy Editor, Journal of Orthopaedic Research
  • 2009-present: Editor-in-Chief, Journal of Orthopaedic Research & Reviews (open access)
  • 2016: Marshall R. Urist, MD Award, 2016 Orthopaedic Research Society

Areas of Research Interest

Effects of physical, mechanical, and chemical stimuli on musculoskeletal cells related to cellular and tissue engineering.

Background

Dr. Hung has been pursuing in-depth multidisciplinary collaborations with faculties and students from the Departments of Biological Sciences, Mechanical Engineering, Chemical Engineering and Orthopaedic Surgery using with state-of-the-art biological and engineering tools to perform research aimed at the study of physical effects (e.g., cell deformation, fluid flow effects, hydrostatic pressure) on cells and tissues, and the incorporation of these forces in strategies to develop functional tissue substitutes of clinical relevance. An understanding of the effects of physical forces on cells is important in the development of effective tissue replacements which mimic or restore normal tissue structure-function in orthopaedic and other load-bearing tissues of the body. Such studies are aimed at alleviating the most prevalent and chronic problems afflicting the musculoskeletal system such as arthritis, and problems related to sports and occupational injuries.

Patents

  1. Hung CT, Ateshian GA, Lima EG, Cook JL, Bian L: Osteochondral implants, arthroplasty methods, devices, and systems. Patent # US 8,608,801.
  2. Lima EG, Sirsi S, Hung CT, Borden MA: Gas-filled microbubbles devices and methods. Patent # US 8,617,892.
  3. Hung CT and O'Connell GD: Tissue culture media containing trimethylamine N-oxide, Patent # US 9,321,993.
  4. Cook JL, Hung CT, Stoker AM, Lima EG: Chondral and osteochondral allograft preservation system. PCT application #PCT/US12/21134. [Contract with MTF tissue bank]
  5. Konofagou EK and Hung CT: Tissue engineering methods, systems and devices employing ultrasound. PCT application #PCT/US2012/034136.
  6. Hung CT, Bulinski JC, Tan AR: Systems, methods, and devices for cell cycle synchronization of progenitor cells to improve uniform differentiation of tissue progenitor cells. CU 15113/T4356-21208PV01. Patent application filed.
  7. Rosenwasser MP, Ateshian GA, Hung CT, Jones BK: Customized bendable osteochondral allografts. PCT filed 3/11/15.

Active Grants

  • Co-Principal Investigator: NIH 1R01AR060361-01 (Ateshian GA, Contact PI): Optimizing nutrient supply in large engineered cartilage tissue constructs ($225,000 yearly DC: $1,742,366), 10% yearly effort - 9/20/10-8/31/16 (no cost extension). 
    • This grant examines the optimization and use of nutrient channels to cultivate large clinically relevant cartilage grafts.
  • Co-Principal Investigator: NIH 1R01AR061988-01 (contact PI: Kaplan D; with Levin M and Vunjak-Novakovic G): Electrotherapeutic strategies for connective tissue repair ($3,650,242 total costs), 7.5% yearly effort - 7/1/11-6/30/16.
    • Three specific aims will be pursued: (a) Biophysical regulation of chondrogenesis and osteogenesis in adult human stem cells, (b) Electrotherapeutic bioreactor models for regeneration of cartilage/bone tissues, and (c) Animal studies of cartilage/bone regeneration.
  • Co-Principal Investigator: CDMRP OR130124 (with Bulinski JC): Electric field stimulation enhances healing of post-traumatic osteoarthritic cartilage ($500,000 direct costs; $643,989 total costs), 8% yearly effort - 10/1/14-9/30/17.
    • The proposal will explore the application of electric fields to promote healing of cartilage lesions by inducing migration of synovial derived stem cells. In vitro studies as well as in vivo studies in a canine cartilage defect model are planned with collaborators at Brown University (Aaron RK) and University of Missouri (Cook JL).
  • Co-Principal Investigator: NYSTEM N13S-005 (with Brown LM): Large-scale biochemical profiling for stem cell research in New York ($1,624,453 total costs) - 4/1/14-3/31/18.
    • The proposal seeks funds to purchase acquire a new liquid chromatograph-mass spectrometer and increase staffing level to support this equipment to support metabolomics and proteomics studies pertaining to stem cell research at Columbia and for other New York state researchers.
  • Investigator: NIH NIBIB 5P41EB002520 (with Vunjak-Novakovic G): Core-Tissue Engineering Bioreactor, 4% yearly effort - 9/1/09-8/31/19.
    • The focus of this core will be on the development and utilization of novel bioreactors designed to precisely control the cellular microenvironment, impart multiple physical stimuli, and enable real time imaging of cells and tissues at various hierarchical scales. Osteochondral (cartilage/bone) tissues and myocardium are selected as paradigms of distinctly different, clinically relevant engineered tissues to serve as models for bioreactor development and validation.
  • Engineering PI: Coulter Foundation/Columbia Technology Ventures WHCF CU12-0369 (with clinical PI: Cook JL): ECHON - Engineered Osteochondral Graft for Joint Repair ($156,478 total costs), 9/1/14-8/31/16 (extension in place to complete work).
    • The project is joint between the Coulter Translational Research Program of the University of Missouri and Columbia University. The project aims to translate proprietary osteochondral graft technology to human cells in culture and in vivo studies.
  • Co-Investigator: N13G-107 NYSTEM IDEA proposal (PI: Lu HH): Stem cell-mediated integrative cartilage repair (total requested $330,000; year 1 total $152,073), 5% effort - 6/1/14-5/31/16.
    • The proposal seeks to develop an electrospun, nano-fibrous polymer interface to facilitate osteochondral graft integration with the host tissue.
  • Principal Investigator: Musculoskeletal Transplant Foundation (MTF) Investigator Grant: Local dexamethasone delivery for osteochondral grafting ($300,000 total costs) - 2/1/15-1/31/18.
    • This application aims to improve osteochondral repair of full thickness cartilage defects by intra-articular delivery of the steroid dexamethasone from engineered osteochondral plugs placed in the graft donor sites as part of an autologous osteochondral transfer procedure. The team includes collaborators from Columbia (Ateshian), the University of Pittsburgh (Marra) and University of Missouri (Cook, Kuroki).
  • Co-Principal Investigator: PUC Chile and COlumbia SEAS Collaborative Engineering Research Seed Grant Program (with LU HH, Valenzuela L, Olguin H): Electrotherapeutics for musculoskeletal tissue repair & regeneration ($20,000 total costs - Hung $5,000) - 1/1/16-12/31/16.
    • This application aims to study the influence of charged electrospun scaffolds and applied electric fields on strategies for cartilage repair and ligament regeneration.
  • Co-Investigator: Orthopaedic Scientific Research Foundation grant application 02-2015 (PI: Shah R): Role of cartilage particulates in synovial joint inflammation ($27,500 total costs) - 1/1/16-12/31/16.
    • This application will analyze synovial fluid from patients undergoing joint arthroplasty for particulates, cytokines and biomarkers.